diff --git a/docs/advanced_features/pd_disaggregation.md b/docs/advanced_features/pd_disaggregation.md
index 21ea7dffe..b40ab11b4 100644
--- a/docs/advanced_features/pd_disaggregation.md
+++ b/docs/advanced_features/pd_disaggregation.md
@@ -262,6 +262,26 @@ python -m sglang.launch_server \
   --max-running-requests 128
 ```
 
+### Advanced Configuration
+
+#### NIXL Backend Selection
+
+By default, NIXL uses the **UCX** backend for KV cache transfers. You can select a different NIXL plugin backend depending on your infrastructure using the environment variable `SGLANG_DISAGGREGATION_NIXL_BACKEND`.
+
+Example: `export SGLANG_DISAGGREGATION_NIXL_BACKEND=LIBFABRIC`
+
+**Available backends:** UCX (default), LIBFABRIC, or any installed NIXL plugin.
+
+Example usage:
+```bash
+export SGLANG_DISAGGREGATION_NIXL_BACKEND=LIBFABRIC
+python -m sglang.launch_server \
+  --model-path meta-llama/Llama-3.1-8B-Instruct \
+  --disaggregation-mode prefill \
+  --disaggregation-transfer-backend nixl \
+  --port 30000
+```
+
 ## ASCEND
 
 ### Usage
diff --git a/python/sglang/srt/disaggregation/nixl/conn.py b/python/sglang/srt/disaggregation/nixl/conn.py
index d3e390c92..7905aae65 100644
--- a/python/sglang/srt/disaggregation/nixl/conn.py
+++ b/python/sglang/srt/disaggregation/nixl/conn.py
@@ -136,14 +136,30 @@ class NixlKVManager(CommonKVManager):
     ):
         super().__init__(args, disaggregation_mode, server_args, is_mla_backend)
         try:
-            from nixl._api import nixl_agent
+            from nixl._api import nixl_agent, nixl_agent_config
         except ImportError as e:
             raise ImportError(
                 "Please install NIXL by following the instructions at "
                 "https://github.com/ai-dynamo/nixl/blob/main/README.md "
                 "to run SGLang with NixlTransferEngine."
             ) from e
-        self.agent = nixl_agent(str(uuid.uuid4()))
+
+        agent_config = nixl_agent_config(backends=[])
+        self.agent = nixl_agent(str(uuid.uuid4()), agent_config)
+
+        backend = envs.SGLANG_DISAGGREGATION_NIXL_BACKEND.get()
+
+        available_plugins = self.agent.get_plugin_list()
+        if backend not in available_plugins:
+            raise ValueError(
+                f"NIXL backend '{backend}' not found. Available: {available_plugins}. "
+                f"Please install the required NIXL plugin or choose from: {available_plugins}"
+            )
+
+        self.agent.create_backend(backend)
+        self.nixl_backend = backend
+        logger.info(f"NIXL KVManager initialized with backend: {backend}")
+
         self.register_buffer_to_engine()
 
         if self.disaggregation_mode == DisaggregationMode.PREFILL:
diff --git a/python/sglang/srt/environ.py b/python/sglang/srt/environ.py
index 5dbd90899..928ec998e 100644
--- a/python/sglang/srt/environ.py
+++ b/python/sglang/srt/environ.py
@@ -234,6 +234,7 @@ class Envs:
     SGLANG_DISAGGREGATION_HEARTBEAT_INTERVAL = EnvFloat(5.0)
     SGLANG_DISAGGREGATION_HEARTBEAT_MAX_FAILURE = EnvInt(2)
     SGLANG_DISAGGREGATION_WAITING_TIMEOUT = EnvInt(300)
+    SGLANG_DISAGGREGATION_NIXL_BACKEND = EnvStr("UCX")
 
     # Scheduler: others:
     SGLANG_EMPTY_CACHE_INTERVAL = EnvFloat(-1)  # in seconds. Set if you observe high memory accumulation over a long serving period.