diff --git a/.github/workflows/pr-test-npu.yml b/.github/workflows/pr-test-npu.yml
index 644464167..de7833571 100644
--- a/.github/workflows/pr-test-npu.yml
+++ b/.github/workflows/pr-test-npu.yml
@@ -29,6 +29,7 @@ jobs:
     runs-on: ubuntu-latest
     outputs:
       main_package: ${{ steps.filter.outputs.main_package || steps.run-mode.outputs.run_all_tests }}
+      multimodal_gen: ${{ steps.filter.outputs.multimodal_gen || steps.run-mode.outputs.run_all_tests }}
     steps:
       - name: Checkout code
         uses: actions/checkout@v4
@@ -56,10 +57,15 @@ jobs:
           filters: |
             main_package:
               - "python/sglang/!(multimodal_gen)/**"
-              - "python/pyproject_other.toml"
+              - "python/pyproject_npu.toml"
               - "scripts/ci/npu/npu_ci_install_dependency.sh"
               - "test/srt/ascend/**"
               - ".github/workflows/pr-test-npu.yml"
+            multimodal_gen:
+              - "python/sglang/multimodal_gen/**"
+              - "python/pyproject_npu.toml"
+              - "scripts/ci/npu_ci_install_dependency.sh"
+              - ".github/workflows/pr-test-npu.yml"
 
   # ==================== PR Gate ==================== #
   pr-gate:
diff --git a/.github/workflows/release-docker-npu-nightly.yml b/.github/workflows/release-docker-npu-nightly.yml
index ef9bc0c06..7b66eba24 100644
--- a/.github/workflows/release-docker-npu-nightly.yml
+++ b/.github/workflows/release-docker-npu-nightly.yml
@@ -1,11 +1,5 @@
 name: Release Docker Images Nightly (NPU)
 on:
-  pull_request:
-    branches:
-      - main
-    paths:
-      - ".github/workflows/release-docker-npu-nightly.yml"
-      - "docker/npu.Dockerfile"
   workflow_dispatch:
   schedule:
     - cron: "0 0 * * *"
diff --git a/docker/npu.Dockerfile b/docker/npu.Dockerfile
index d6fb7d2cf..e49551b19 100644
--- a/docker/npu.Dockerfile
+++ b/docker/npu.Dockerfile
@@ -73,7 +73,7 @@ RUN (${PIP_INSTALL} pybind11) \
 
 # Install SGLang
 RUN git clone https://github.com/sgl-project/sglang --branch $SGLANG_TAG && \
-    (cd sglang/python && rm -rf pyproject.toml && mv pyproject_other.toml pyproject.toml && ${PIP_INSTALL} -v .[srt_npu]) && \
+    (cd sglang/python && rm -rf pyproject.toml && mv pyproject_npu.toml pyproject.toml && ${PIP_INSTALL} -v .[all_npu]) && \
     rm -rf sglang
 
 # Install Deep-ep
diff --git a/docs/platforms/ascend_npu.md b/docs/platforms/ascend_npu.md
index 1a4f14ae8..d91382f65 100644
--- a/docs/platforms/ascend_npu.md
+++ b/docs/platforms/ascend_npu.md
@@ -100,8 +100,8 @@ pip install ./custom_ops-2.0.$DEVICE_TYPE-cp311-cp311-linux_aarch64.whl
 # Use the last release branch
 git clone https://github.com/sgl-project/sglang.git
 cd sglang
-mv python/pyproject_other.toml python/pyproject.toml
-pip install -e python[srt_npu]
+mv python/pyproject_npu.toml python/pyproject.toml
+pip install -e python[all_npu]
 ```
 
 ### Method 2: Using Docker Image
diff --git a/python/pyproject_npu.toml b/python/pyproject_npu.toml
new file mode 100644
index 000000000..70403f8ee
--- /dev/null
+++ b/python/pyproject_npu.toml
@@ -0,0 +1,146 @@
+[build-system]
+requires = ["setuptools>=61.0", "setuptools-scm>=8.0", "wheel", "grpcio-tools==1.75.1"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "sglang"
+dynamic = ["version"]
+description = "SGLang is a fast serving framework for large language models and vision language models."
+readme = "README.md"
+requires-python = ">=3.10"
+license = { file = "LICENSE" }
+classifiers = [
+  "Programming Language :: Python :: 3",
+  "License :: OSI Approved :: Apache Software License",
+]
+
+dependencies = [
+  "IPython",
+  "aiohttp",
+  "anthropic>=0.20.0",
+  "blobfile==3.0.0",
+  "build",
+  "compressed-tensors",
+  "decord2",
+  "datasets",
+  "einops",
+  "fastapi",
+  "gguf",
+  "hf_transfer",
+  "huggingface_hub",
+  "interegular",
+  "llguidance>=0.7.11,<0.8.0",
+  "modelscope",
+  "msgspec",
+  "ninja",
+  "numpy",
+  "openai-harmony==0.0.4",
+  "openai==2.6.1",
+  "orjson",
+  "outlines==0.1.11",
+  "packaging",
+  "partial_json_parser",
+  "pillow",
+  "prometheus-client>=0.20.0",
+  "psutil",
+  "py-spy",
+  "pybase64",
+  "pydantic",
+  "python-multipart",
+  "pyzmq>=25.1.2",
+  "requests",
+  "scipy",
+  "sentencepiece",
+  "setproctitle",
+  "soundfile==0.13.1",
+  "tiktoken",
+  "timm==1.0.16",
+  "torchao==0.9.0",
+  "tqdm",
+  "transformers==4.57.1",
+  "uvicorn",
+  "uvloop",
+  "xgrammar==0.1.27",
+  "grpcio==1.75.1", # keep it align with compile_proto.py
+  "grpcio-tools==1.75.1", # keep it align with compile_proto.py
+  "grpcio-reflection==1.75.1", # required by srt/entrypoints/grpc_server.py
+]
+
+[project.optional-dependencies]
+checkpoint-engine = ["checkpoint-engine==0.1.2"]
+diffusion = [
+    "PyYAML==6.0.1",
+    "cloudpickle",
+    "diffusers==0.36.0",
+    "imageio==2.36.0",
+    "imageio-ffmpeg==0.5.1",
+    "moviepy>=2.0.0",
+    "opencv-python==4.10.0.84",
+    "remote-pdb",
+    "cache-dit==1.1.8"
+]
+
+tracing = [
+  "opentelemetry-api",
+  "opentelemetry-exporter-otlp",
+  "opentelemetry-exporter-otlp-proto-grpc",
+  "opentelemetry-sdk",
+]
+
+test = [
+  "accelerate",
+  "expecttest",
+  "gguf",
+  "jsonlines",
+  "matplotlib",
+  "pandas",
+  "peft",
+  "pytest",
+  "sentence_transformers",
+  "tabulate",
+]
+
+# https://docs.sglang.io/platforms/ascend_npu.html
+srt_npu = []
+all_npu = ["sglang[diffusion]"]
+dev_npu = ["sglang[all_npu]", "sglang[test]"]
+
+[project.urls]
+"Homepage" = "https://github.com/sgl-project/sglang"
+"Bug Tracker" = "https://github.com/sgl-project/sglang/issues"
+
+[project.scripts]
+sglang = "sglang.cli.main:main"
+
+[tool.setuptools.package-data]
+"sglang" = [
+  "srt/**/*",
+  "jit_kernel/**/*"
+]
+
+[tool.setuptools.packages.find]
+exclude = [
+  "assets*",
+  "benchmark*",
+  "docs*",
+  "dist*",
+  "playground*",
+  "scripts*",
+  "tests*",
+]
+
+[tool.wheel]
+exclude = [
+  "assets*",
+  "benchmark*",
+  "docs*",
+  "dist*",
+  "playground*",
+  "scripts*",
+  "tests*",
+]
+
+[tool.setuptools_scm]
+root = ".."
+version_file = "sglang/_version.py"
+git_describe_command = ["git", "describe", "--tags", "--long", "--match", "v*"]
diff --git a/python/pyproject_other.toml b/python/pyproject_other.toml
index a00edee53..e1312a46e 100755
--- a/python/pyproject_other.toml
+++ b/python/pyproject_other.toml
@@ -99,9 +99,6 @@ diffusion_hip = [
   "runai_model_streamer",
 ]
 
-# https://docs.sglang.io/platforms/ascend_npu.html
-srt_npu = ["sglang[runtime_common]"]
-
 # For Intel Gaudi(device : hpu) follow the installation guide
 # https://docs.vllm.ai/en/latest/getting_started/gaudi-installation.html
 srt_hpu = ["sglang[runtime_common]"]
@@ -145,12 +142,10 @@ test = [
 ]
 
 all_hip = ["sglang[srt_hip]"]
-all_npu = ["sglang[srt_npu]"]
 all_hpu = ["sglang[srt_hpu]"]
 all_musa = ["sglang[srt_musa]", "sglang[diffusion_musa]"]
 
 dev_hip = ["sglang[all_hip]", "sglang[test]"]
-dev_npu = ["sglang[all_npu]", "sglang[test]"]
 dev_hpu = ["sglang[all_hpu]", "sglang[test]"]
 dev_musa = ["sglang[all_musa]", "sglang[test]"]
 
diff --git a/scripts/ci/npu/npu_ci_install_dependency.sh b/scripts/ci/npu/npu_ci_install_dependency.sh
index a1dbe0e35..a4ce9bda9 100755
--- a/scripts/ci/npu/npu_ci_install_dependency.sh
+++ b/scripts/ci/npu/npu_ci_install_dependency.sh
@@ -17,7 +17,9 @@ apt update -y && apt install -y \
     clang \
     locales \
     ccache \
-    ca-certificates
+    ca-certificates \
+    libgl1 \
+    libglib2.0-0
 update-ca-certificates
 ${PIP_INSTALL} --upgrade pip
 # Pin wheel to 0.45.1, REF: https://github.com/pypa/wheel/issues/662
@@ -62,5 +64,5 @@ wget https://sglang-ascend.obs.cn-east-3.myhuaweicloud.com/ops/custom_ops-1.0.$D
 pip install ./custom_ops-1.0.$DEVICE_TYPE-cp311-cp311-linux_aarch64.whl
 
 ### Install SGLang
-rm -rf python/pyproject.toml && mv python/pyproject_other.toml python/pyproject.toml
+rm -rf python/pyproject.toml && mv python/pyproject_npu.toml python/pyproject.toml
 ${PIP_INSTALL} -v -e "python[dev_npu]"
diff --git a/scripts/release/README.md b/scripts/release/README.md
index e564cf1d4..6a8d2351c 100644
--- a/scripts/release/README.md
+++ b/scripts/release/README.md
@@ -21,6 +21,7 @@ python scripts/release/bump_sglang_version.py 0.5.3rc0
 - `docs/platforms/ascend_npu.md`
 - `python/pyproject.toml`
 - `python/pyproject_other.toml`
+- `python/pyproject_npu.toml`
 - `python/sglang/version.py`
 
 ### `bump_kernel_version.py`
diff --git a/scripts/release/bump_sglang_version.py b/scripts/release/bump_sglang_version.py
index 76d26383c..73e79fdcf 100755
--- a/scripts/release/bump_sglang_version.py
+++ b/scripts/release/bump_sglang_version.py
@@ -27,6 +27,7 @@ def main():
         Path("docs/platforms/ascend_npu.md"),
         Path("python/pyproject.toml"),
         Path("python/pyproject_other.toml"),
+        Path("python/pyproject_npu.toml"),
         Path("python/pyproject_cpu.toml"),
         Path("python/pyproject_xpu.toml"),
         Path("python/sglang/version.py"),