diff --git a/.github/workflows/release-pypi-nightly.yml b/.github/workflows/release-pypi-nightly.yml
new file mode 100644
index 000000000..e841e5868
--- /dev/null
+++ b/.github/workflows/release-pypi-nightly.yml
@@ -0,0 +1,160 @@
+name: Release PyPI Nightly Wheels
+
+on:
+  # Triggered by nightly Docker workflow to use same commit
+  repository_dispatch:
+    types: [nightly-release]
+  # Manual trigger for testing
+  workflow_dispatch:
+    inputs:
+      commit_sha:
+        description: 'Specific commit SHA to build (leave empty for latest)'
+        required: false
+        type: string
+
+concurrency:
+  group: release-pypi-nightly-${{ github.ref }}
+  cancel-in-progress: true
+
+jobs:
+  build-nightly-wheel:
+    if: github.repository == 'sgl-project/sglang'
+    runs-on: ubuntu-latest
+    outputs:
+      nightly_version: ${{ steps.gen_version.outputs.nightly_version }}
+      commit_hash: ${{ steps.gen_version.outputs.commit_hash }}
+      build_date: ${{ steps.gen_version.outputs.build_date }}
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          # Use commit from: 1) Docker workflow, 2) manual input, 3) latest main
+          ref: ${{ github.event.client_payload.commit_sha || inputs.commit_sha || github.sha }}
+          fetch-depth: 0  # Need full history for version generation
+
+      - name: Set up Python
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.10"
+
+      - name: Generate nightly version
+        id: gen_version
+        run: |
+          # Get base version from version.py
+          BASE_VERSION=$(cat python/sglang/version.py | cut -d'"' -f2)
+
+          # Get commit info
+          COMMIT_HASH=$(git rev-parse --short HEAD)
+          COMMIT_COUNT=$(git rev-list --count HEAD)
+
+          # Get current date in YYYY-MM-DD format
+          BUILD_DATE=$(date -u +%Y-%m-%d)
+
+          # Generate nightly version following PEP 440
+          # Format: {base_version}.dev{commit_count}+g{commit_hash}
+          NIGHTLY_VERSION="${BASE_VERSION}.dev${COMMIT_COUNT}+g${COMMIT_HASH}"
+
+          echo "Base version: ${BASE_VERSION}"
+          echo "Nightly version: ${NIGHTLY_VERSION}"
+          echo "Commit: ${COMMIT_HASH}"
+          echo "Build date: ${BUILD_DATE}"
+
+          echo "nightly_version=${NIGHTLY_VERSION}" >> $GITHUB_OUTPUT
+          echo "commit_hash=${COMMIT_HASH}" >> $GITHUB_OUTPUT
+          echo "base_version=${BASE_VERSION}" >> $GITHUB_OUTPUT
+          echo "build_date=${BUILD_DATE}" >> $GITHUB_OUTPUT
+
+      - name: Update pyproject.toml with nightly version
+        run: |
+          cd python
+          BASE_VERSION=$(cat sglang/version.py | cut -d'"' -f2)
+          NIGHTLY_VERSION="${{ steps.gen_version.outputs.nightly_version }}"
+
+          # Update version (temporary, not committed)
+          sed -i "s/version = \"${BASE_VERSION}\"/version = \"${NIGHTLY_VERSION}\"/" pyproject.toml
+
+          # Verify update
+          echo "Updated version in pyproject.toml:"
+          grep "^version" pyproject.toml
+
+      - name: Install build dependencies
+        run: |
+          cd python
+          pip install build wheel setuptools
+
+      - name: Build wheel
+        run: |
+          cd python
+          cp ../README.md ../LICENSE .
+          python3 -m build --wheel
+
+          # List built wheels
+          echo "Built wheel:"
+          ls -lh dist/
+
+      - name: Upload wheel artifact
+        uses: actions/upload-artifact@v4
+        with:
+          name: nightly-wheel
+          path: python/dist/*.whl
+          retention-days: 7
+
+  release-nightly:
+    needs: build-nightly-wheel
+    runs-on: ubuntu-latest
+    environment: 'prod'
+    steps:
+      - uses: actions/checkout@v4
+
+      - name: Download wheel artifact
+        uses: actions/download-artifact@v4
+        with:
+          name: nightly-wheel
+          path: dist/
+
+      - name: List downloaded wheels
+        run: |
+          echo "Downloaded wheel:"
+          ls -lh dist/
+
+      - name: Create GitHub Release for nightly wheel
+        uses: softprops/action-gh-release@v2
+        with:
+          tag_name: nightly-${{ needs.build-nightly-wheel.outputs.build_date }}-${{ needs.build-nightly-wheel.outputs.commit_hash }}
+          name: Nightly Build ${{ needs.build-nightly-wheel.outputs.build_date }} (${{ needs.build-nightly-wheel.outputs.commit_hash }})
+          repository: sgl-project/whl
+          token: ${{ secrets.GH_PAT_FOR_WHL_RELEASE }}
+          prerelease: true
+          body: |
+            Nightly build from commit ${{ github.sha }}
+            Build date: ${{ needs.build-nightly-wheel.outputs.build_date }}
+            Version: ${{ needs.build-nightly-wheel.outputs.nightly_version }}
+          files: |
+            dist/*.whl
+
+      - name: Clone wheel index repository
+        run: |
+          git clone https://oauth2:${WHL_TOKEN}@github.com/sgl-project/whl.git sgl-whl
+          cd sgl-whl
+          git config --local user.name "sglang-bot"
+          git config --local user.email "sglangbot@gmail.com"
+        env:
+          WHL_TOKEN: ${{ secrets.GH_PAT_FOR_WHL_RELEASE }}
+
+      - name: Set up Python
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.10"
+
+      - name: Update wheel index
+        run: |
+          python3 scripts/update_nightly_whl_index.py \
+            --commit-hash ${{ needs.build-nightly-wheel.outputs.commit_hash }} \
+            --nightly-version ${{ needs.build-nightly-wheel.outputs.nightly_version }} \
+            --build-date ${{ needs.build-nightly-wheel.outputs.build_date }}
+
+      - name: Push wheel index
+        run: |
+          cd sgl-whl
+          git add -A
+          git diff --staged --quiet || git commit -m "Update nightly wheel index for commit ${{ needs.build-nightly-wheel.outputs.commit_hash }}"
+          git push
diff --git a/scripts/update_nightly_whl_index.py b/scripts/update_nightly_whl_index.py
new file mode 100755
index 000000000..58079eb26
--- /dev/null
+++ b/scripts/update_nightly_whl_index.py
@@ -0,0 +1,170 @@
+#!/usr/bin/env python3
+"""
+Update the wheel index for nightly SGLang releases.
+
+This script generates a single PyPI-compatible index.html file at nightly/index.html
+containing all historical nightly builds, ordered by commit count (newest first).
+
+Reference: https://github.com/flashinfer-ai/flashinfer/blob/v0.2.0/scripts/update_whl_index.py
+"""
+
+import argparse
+import hashlib
+import pathlib
+import re
+
+
+def compute_sha256(file_path: pathlib.Path) -> str:
+    """Compute SHA256 hash of a file."""
+    sha256_hash = hashlib.sha256()
+    with open(file_path, "rb") as f:
+        for byte_block in iter(lambda: f.read(4096), b""):
+            sha256_hash.update(byte_block)
+    return sha256_hash.hexdigest()
+
+
+def update_wheel_index(commit_hash: str, nightly_version: str, build_date: str = None):
+    """Update the wheel index for nightly releases.
+
+    Creates a single index at nightly/index.html containing all historical nightlies.
+
+    Args:
+        commit_hash: Short git commit hash (e.g., 'c5f1e86')
+        nightly_version: Full nightly version string (e.g., '0.5.6.post1.dev7716+gc5f1e86')
+        build_date: Build date in YYYY-MM-DD format (e.g., '2025-12-13')
+    """
+    dist_dir = pathlib.Path("dist")
+    whl_repo_dir = pathlib.Path("sgl-whl")
+
+    if not dist_dir.exists():
+        print(f"Warning: {dist_dir} does not exist, skipping index update")
+        return
+
+    # Base URL for wheels stored in GitHub Releases
+    base_url = "https://github.com/sgl-project/whl/releases/download"
+    # Use date-based tag if build_date is provided, otherwise fall back to commit-only
+    if build_date:
+        release_tag = f"nightly-{build_date}-{commit_hash}"
+    else:
+        release_tag = f"nightly-{commit_hash}"
+
+    # Create nightly directory structure following PEP 503
+    # /nightly/index.html -> links to sglang/
+    # /nightly/sglang/index.html -> contains wheel links
+    nightly_dir = whl_repo_dir / "nightly"
+    nightly_dir.mkdir(parents=True, exist_ok=True)
+
+    sglang_dir = nightly_dir / "sglang"
+    sglang_dir.mkdir(parents=True, exist_ok=True)
+
+    root_index = nightly_dir / "index.html"
+    package_index = sglang_dir / "index.html"
+
+    print(f"\nUpdating nightly wheel index")
+    print(f"  Root index: {root_index}")
+    print(f"  Package index: {package_index}")
+
+    # Read existing package index if it exists
+    existing_links = []
+    if package_index.exists():
+        with open(package_index, "r") as f:
+            content = f.read()
+            # Extract existing links (skip header and HTML boilerplate)
+            existing_links = [
+                line for line in content.split("\n") if line.startswith("<a href=")
+            ]
+
+    # Generate new links for current wheels
+    new_links = []
+    for wheel_path in sorted(dist_dir.glob("*.whl")):
+        try:
+            filename = wheel_path.name
+            sha256 = compute_sha256(wheel_path)
+
+            # URL format: {base_url}/{release_tag}/{filename}#sha256={hash}
+            wheel_url = f"{base_url}/{release_tag}/{filename}#sha256={sha256}"
+            link = f'<a href="{wheel_url}">{filename}</a><br>'
+
+            new_links.append(link)
+            print(f"  Added: {filename}")
+        except Exception as e:
+            print(f"  Error processing {wheel_path.name}: {e}")
+            continue
+
+    if not new_links:
+        print("  No new wheels to add")
+        return
+
+    # Combine existing and new links (new links first for latest)
+    all_links = new_links + existing_links
+
+    # Remove duplicates while preserving order (newer first)
+    seen = set()
+    unique_links = []
+    for link in all_links:
+        # Extract filename from link to check for duplicates
+        filename_match = re.search(r">([^<]+\.whl)</a>", link)
+        if filename_match:
+            filename = filename_match.group(1)
+            if filename not in seen:
+                seen.add(filename)
+                unique_links.append(link)
+
+    # Write root index (links to sglang package directory)
+    with open(root_index, "w") as f:
+        f.write("<!DOCTYPE html>\n")
+        f.write('<a href="sglang/">sglang</a>\n')
+
+    print(f"  Written root index: {root_index}")
+
+    # Write package index in minimal format (matching production sgl-kernel index)
+    with open(package_index, "w") as f:
+        f.write("<!DOCTYPE html>\n")
+        f.write("<h1>SGLang Nightly Wheels</h1>\n")
+        # Write links only
+        f.write("\n".join(unique_links))
+        f.write("\n")
+
+    print(f"  Written {len(unique_links)} total wheels to {package_index}")
+    print(f"\nDone! Users can install with:")
+    print(
+        f"  pip install sglang --pre --extra-index-url https://sgl-project.github.io/whl/nightly/"
+    )
+
+
+def main():
+    parser = argparse.ArgumentParser(
+        description="Update wheel index for nightly SGLang releases"
+    )
+    parser.add_argument(
+        "--commit-hash",
+        type=str,
+        required=True,
+        help="Short git commit hash (e.g., 'c5f1e86')",
+    )
+    parser.add_argument(
+        "--nightly-version",
+        type=str,
+        required=True,
+        help="Full nightly version string (e.g., '0.5.6.post1.dev7716+gc5f1e86')",
+    )
+    parser.add_argument(
+        "--build-date",
+        type=str,
+        required=False,
+        help="Build date in YYYY-MM-DD format (e.g., '2025-12-13')",
+    )
+
+    args = parser.parse_args()
+
+    print(f"Updating nightly wheel index")
+    print(f"  Commit: {args.commit_hash}")
+    print(f"  Version: {args.nightly_version}")
+    if args.build_date:
+        print(f"  Build date: {args.build_date}")
+
+    update_wheel_index(args.commit_hash, args.nightly_version, args.build_date)
+
+
+if __name__ == "__main__":
+    main()